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Author Topic:   A Case Study: Genetic evidence in support of a shared Eurasian-North African dairying
Thought2
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posted 06 April 2005 05:22 PM     Click Here to See the Profile for Thought2     Edit/Delete Message   Reply w/Quote
Thought Posts:

Human Genetics (Online Early)

Genetic evidence in support of a shared Eurasian-North African dairying origin

By Sean Myles

Abstract
The process by which pastoralism and agriculture spread from the Fertile Crescent over the past 10,000 years has been the subject of intense investigation by geneticists, linguists and archaeologists. However, no consensus has been reached as to whether this Neolithic transition is best characterized by a demic diffusion (with a significant genetic input from migrating farmers) or a cultural diffusion (without substantial migration of farmers). Milk consumption and thus lactose tolerance are assumed to have spread with pastoralism and we propose that by looking at the relevant mutations in and around the lactase gene in human populations, we can gain insight into the origin(s) and spread of dairying. We genotyped the putatively causal allele for lactose tolerance (–13910T) and constructed haplotypes from several polymorphisms in and around the lactase gene (LCT) in three North African Berber populations and compared our results with previously published data. We found that the frequency of the –13910T allele predicts the frequency of lactose tolerance in several Eurasian and North African Berber populations but not in most sub-Saharan African populations. Our analyses suggest that contemporary Berber populations possess the genetic signature of a past migration of pastoralists from the Middle East and that they share a dairying origin with Europeans and Asians, but not with sub-Saharan Africans.

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Thought2
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posted 06 April 2005 05:29 PM     Click Here to See the Profile for Thought2     Edit/Delete Message   Reply w/Quote
Thought Writes:

I have the study. I will be posting excerpts for analysis and discussion of the more modern and subtle forms of the “Hamitic Hypothesis”. But lets start with this context from Keita:

American Journal of Human Biology
16: 679-689 (2004)
S.O.Y. Keita

“However, the theory that has had the greatest influence, and still persists in one form or another in some disciplines, was put forth by Seligman (1930), who stated that the peoples of the Horn-Nile basin and supra-Saharan regions were primarily the descendents of southwest Asian immigrants into Africa (i.e., settler colonists), who arrived at some time in the unspecified past. These immigrants were called “Hamites” (a term not original to Seligman), and constructed as “dark pastoral Europeans” who allegedly brought “Hamitic” languages, narrow noses and faces, linear body builds, lighter skin coloration, and any “significant” cultural innovation to Africa…”

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Thought2
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posted 06 April 2005 06:55 PM     Click Here to See the Profile for Thought2     Edit/Delete Message   Reply w/Quote
Thought Posts:
Human Genetics (Online Early)

Genetic evidence in support of a shared Eurasian-North African dairying origin

By Sean Myles

"The transition from a hunter-gatherer lifestyle to one including food production has had profound effects on the technology, demography, social organization and even the biology of most populations (Diamond 1998)."

Thought Writes:

It seems the author is applying Diamonds theory from Guns, Germs and Steel to the development of social complexity in Northern Africa.

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Thought2
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posted 06 April 2005 06:57 PM     Click Here to See the Profile for Thought2     Edit/Delete Message   Reply w/Quote
Thought Posts:
Human Genetics (Online Early)

Genetic evidence in support of a shared Eurasian-North African dairying origin

By Sean Myles

Samples:

33 Mzab-Wargla speakers
39 Tamazight speakers from Amizmiz Morocco
33 Tamazight speakers from Middle Atlas Morocco

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Thought2
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posted 06 April 2005 07:15 PM     Click Here to See the Profile for Thought2     Edit/Delete Message   Reply w/Quote
Thought Posts:

Human Genetics (Online Early)

Genetic evidence in support of a shared Eurasian-North African dairying origin

By Sean Myles

"Two contrasting population models have been put forward for this transition....The first model, demic diffusion, attributes the spread of framing to the local growth and expansion of framers. The second model, cultural diffusion, involves farming being passed fron one local group to the next without substantial movement of farming populations....It is important to note, however, that these two models are not mutually exclusive and that in fact both processes probably contributed to the expansion of agriculture and pastoralism."

"It has previously been shown that, while the frequency of -13910T strongly predicts the frequency of lactose tolerance in Northern Europeans, this is not the case for many Sub-Saharan milk-drinking populations."

"We propose that the observed correlation between the frequencies of the -13910T allele and lactose tolerance in Eurasian and Berber populations and the abscence of -13910T in several sub-saharan African dairying populations supports a scenario in which the Berber share a dairying origin with European and Asian pastoralists but not with sub-saharan African pastoralists."

Thought Writes:

Modern Berbers are primarily indigenous African based upon Y-Chromosome analysis and primarily Eurasian based upon mtDNA analysis. It seems likely therefore that Berbers share in the -13910T allele with Eurasians because of post neolithic gene flow from Eurasia. Not mysterious, wandering neolithic "Caucasoids".

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Thought2
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posted 06 April 2005 08:47 PM     Click Here to See the Profile for Thought2     Edit/Delete Message   Reply w/Quote
quote:
Originally posted by Thought2:

Thought Writes:

Modern Berbers are primarily indigenous African based upon Y-Chromosome analysis and primarily Eurasian based upon mtDNA analysis.


Thought Posts:

The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool.
Am J Hum Genet. 2004 Nov;75(5):910-8. Epub 2004 Sep 20.

Frequency of Haplogroup H:

Basques (Spain) 51.9%
Galicia 45.1%
Andalusia 43.7%
Berbers Morocco 36.8%
Tunisia 26.5%
Algeria 25.6%
Arabian Peninsula 10.6%
Berbers (Egypt) 1.4%

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Super car
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posted 06 April 2005 11:34 PM     Click Here to See the Profile for Super car     Edit/Delete Message   Reply w/Quote
quote:
Originally posted by Thought2:
Thought Writes:

I have the study. I will be posting excerpts for analysis and discussion of the more modern and subtle forms of the “Hamitic Hypothesis”. But lets start with this context from Keita:

American Journal of Human Biology
16: 679-689 (2004)
S.O.Y. Keita

“However, the theory that has had the greatest influence, and still persists in one form or another in some disciplines, was put forth by Seligman (1930), who stated that the peoples of the Horn-Nile basin and supra-Saharan regions were primarily the descendents of southwest Asian immigrants into Africa (i.e., settler colonists), who arrived at some time in the unspecified past. These immigrants were called “Hamites” (a term not original to Seligman), and constructed as “dark pastoral Europeans” who allegedly brought “Hamitic” languages, narrow noses and faces, linear body builds, lighter skin coloration, and any “significant” cultural innovation to Africa…”


Simply put, the testimony of ancestral fossils and the haven for the deepest clades of paternal lineages in continental Africa puts any hypothesis of the kind (in all its manifestations: subtle or not so subtle) put to sleep.

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Thought2
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posted 06 April 2005 11:58 PM     Click Here to See the Profile for Thought2     Edit/Delete Message   Reply w/Quote
quote:
Originally posted by Thought2:
Thought Writes:

I have the study. I will be posting excerpts for analysis and discussion of the more modern and subtle forms of the “Hamitic Hypothesis”. But lets start with this context from Keita:

American Journal of Human Biology
16: 679-689 (2004)
S.O.Y. Keita

“However, the theory that has had the greatest influence, and still persists in one form or another in some disciplines, was put forth by Seligman (1930), who stated that the peoples of the Horn-Nile basin and supra-Saharan regions were primarily the descendents of southwest Asian immigrants into Africa (i.e., settler colonists), who arrived at some time in the unspecified past. These immigrants were called “Hamites” (a term not original to Seligman), and constructed as “dark pastoral Europeans” who allegedly brought “Hamitic” languages, narrow noses and faces, linear body builds, lighter skin coloration, and any “significant” cultural innovation to Africa…”


Thought Writes:

Perhaps as a early 20th Century European Jew, Seligman was desperately seeking answers to the questions being raised at the time. These questions, rooted in the pre-Darwinian theories of Blumenbach ultimately expressed themselves in the Third Reich.

[This message has been edited by Thought2 (edited 07 April 2005).]

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Thought2
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posted 07 April 2005 12:30 AM     Click Here to See the Profile for Thought2     Edit/Delete Message   Reply w/Quote
quote:
Originally posted by Thought2:
Thought Writes:

Perhaps as a early 20th Century European Jew, Seligman was desperately seeking answers to the questions being raised at the time. These questions, rooted in the pre-Darwinian theories of Blumenbach ultimately expressed themselves in the Third Reich.

[This message has been edited by Thought2 (edited 07 April 2005).]


Thought Writes:

Interestingly enough, two years after the Nazi's took power in Germany :

"Modern criticism of the biological significance of "race" can be dated to the publication in 1935 of a book by Julian Huxley and A.C. Haddon: We Europeans: a survey of "racial" problems (London: Jonathan Cape, 1935)."

"This popular "anti-racist" book appeared to have the eminent authors of Julian Huxley and A. C. Haddon, but according to Elazar Barkan’s The Retreat of Scientific Racism (New York, 1992) much of it was written by Charles Singer and Charles Seligman"



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rasol
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posted 14 April 2005 08:48 AM     Click Here to See the Profile for rasol     Edit/Delete Message   Reply w/Quote
Ausar posts:
quote:
I just don't see why many are so quick to claim the Imazighen because they really didn't accomplish much in terms of high culture. Most of the Imazighen borrowed heavily from cultures surrounding them.

As you must know, the Imazighen are battling for their cultural identity against the Arabisation drive. This issue is similar for them as it is for the Sa3eadi in Egypt.

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ausar
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posted 14 April 2005 01:47 PM     Click Here to See the Profile for ausar     Edit/Delete Message   Reply w/Quote
Yeah I know about the Imazgihen fight against Arabization. I really feel for many from Kaybila to parts of Souss in southern Morocco. However, I have also seen people like Kaybles migrate to America and make outrageous claims that every Berber is white skinned with blondish hair. The Imazighen people are hetrogenous people ranging from southern European looking like the Kaybeles to medium brown like Chueleh down to black like the Haratin. The pressence of light haired people amongst the Imazighen has been greatly exagerated.


Plus not all so-called Berbers all call themselves Imazghen,and each have their own name for themselves. Tuaregs call themselves Kel Tamelsheq which means peole of the veil.


Many African Americans might even have some Tuareg ancestry because the modern Tuareg are spread out from Algeria down to Burkino Faso.


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rasol
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posted 14 April 2005 02:02 PM     Click Here to See the Profile for rasol     Edit/Delete Message   Reply w/Quote
I understsand that Tuareg actually means 'thief' in the native tongue, which is too bad, beause it is an elegant sounding name.

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Thought2
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posted 14 April 2005 03:48 PM     Click Here to See the Profile for Thought2     Edit/Delete Message   Reply w/Quote
quote:
Originally posted by ausar:

Many African Americans might even have some Tuareg ancestry because the modern Tuareg are spread out from Algeria down to Burkino Faso.


Thought Writes:

If one considers the mtDNA haplogroup U6 as the signature NW African gene then many West African's and African-American's probably have **some** paleolithic NW African heritage.

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lamin
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posted 14 April 2005 08:23 PM     Click Here to See the Profile for lamin     Edit/Delete Message   Reply w/Quote
Sean Myles is off base. Pastoralism is practiced widely in Africa--as far south as with the Zulu. So what is this talk about so-called "sub-Saharan"( a category so broad as to be meaningless) peoples not having the allele for lactose tolerance. The Hausa are cattle rearers, the Masai, Malinke, the Tutsi, etc.--in fact all savanah and grassland dwelling Africans reared cattle.

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lamin
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posted 14 April 2005 08:37 PM     Click Here to See the Profile for lamin     Edit/Delete Message   Reply w/Quote
From Miles--posted by T2

quote:
We found that the frequency of the –13910T allele predicts the frequency of lactose tolerance in several Eurasian and North African Berber populations but not in most sub-Saharan African populations.

I find this a bit confusing: is it that there are other alleles that code for lactose tolerance in Africa or is that only 13910T codes for it?


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rasol
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posted 14 April 2005 08:57 PM     Click Here to See the Profile for rasol     Edit/Delete Message   Reply w/Quote
quote:
Originally posted by lamin:
From Miles--posted by T2

I find this a bit confusing: is it that there are other alleles that code for lactose tolerance in Africa or is that [b]only 13910T codes for it?


[/B]


Just the opposite in fact:


The ability to digest the milk sugar lactose as an adult (lactase persistence) is a variable genetic trait in human populations. The lactase-persistence phenotype is found at low frequencies in the majority of populations in sub-Saharan Africa that have been tested, but, in some populations, particularly pastoral groups, it is significantly more frequent. We typed this polymorphism in 1,671 individuals from 20 distinct cultural groups in seven African countries. It was possible to match seven of the groups tested with groups from the literature for whom phenotypic information is available. In five of these groups, the published frequencies of lactase persistence are >/=25%. We found the T allele to be so rare that it cannot explain the frequency of the lactase-persistence phenotype throughout Africa.

The T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in Africans.

Mulcare CA, Weale ME, Jones AL, Connell B, Zeitlyn D, Tarekegn A, Swallow DM, Bradman N, Thomas MG.

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